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A Digital Perfusion Phantom for T1-weighted DCE-MRI

Recently, novel Compressed Sensing methods have been proposed that promise very high undersampling factors in the spatial as well as temporal domain. However, it is unclear if these advanced reconstruction techniques preserve the true dynamics of the contrast enhancement, which otherwise could have significant impact on the quantitative analysis of the contrast-agent kinetics. In the latter case, a noisy image that reflects the true underlying dynamics would be more favorable than a beautified image that shows less noise and undersampling artifacts but deviates from the true course of contrast enhancement. To investigate these effects, we developed an extension to the well-known analytical Shepp-Logan phantom in the temporal dimension to simulate contrast enhancement in arteries and in healthy and pathological  tissue. Unlike image-based approaches, a k-space based phantom allows for accurate sampling along arbitrary trajectories. This enables assessing the influence  of k-space sampling strategies as well as the evaluation of reconstruction techniques for dynamic imaging. MATLAB source code for the phantom and for the generation of the contrast dynamics will be made available online here.


Contact the author Opens internal link in new windowRobert Grimm with questions, or if you want to be informed about updates. Email: robert.grimm(at)


Related Publication: 


Related Publication:
Grimm, Robert; Churt, Johannes; Fieselmann, Andreas; Block, Kai Tobias; Kiefer, Berthold; Hornegger, Joachim
Proceedings of International Society for Magnetic Resonance in Medicine (ISMRM 20th Annual Meeting), Melbourne (Australia), May 5-11, pp. 2559, 2012 (BiBTeX, Who cited this?)


Initiates file downloadInitial release (1.0). Write me an email robert.grimm(at) to be notified about updates.


09.05.2012Initial release